THIAPRIL
The Right Combination!
Ramipril 5mg/Hydrochlorothiazide 12.5mg
Rational for Combination Therapy
- Targets multiple mechanisms of hypertension
- Effectiveness of monotherapy is limited by stimulation of counter-regulatory mechanisms
- Majority of patients are less responsive to monotherapy
- Prompt blood pressure control
- Improved compliance (offsetting side effects)
- Addresses global risk / burden
Why Ramitace?
- It’s All About Evidence:
- Most researched of all the ACEI’s
- ACEI with greatest affinity for the ACE enzyme
- Only ACEI with conclusive evidence of preventing CV events (Recurrent Stroke), independent of BP reduction, in patients at risk
- Only ACEI with conclusive evidence of reversal of LVH in patients at risk of HF
ACE Inhibitor-Thiazide Diuretic Combination: Dosage Regimen:
New Patients:
- Start with ½ tablet of Thiapril once daily
- Then step up to 1 tablet daily after 2-4 weeks
Patients on ACE-I :
- 1 tab of Thiapril once dly
- If required, step up to 2 tablets once daily after 3-4 weeks
- If more than 2 agents are required, add another class (preferably a CCB)
ONCE DAILY THIAPRIL……
- Effective BP control for a full 24 hrs – get to target!
- Thiapril therapy provide Cardio & Vascular Protection in a broad range of patients – reduce CV risk (70% of all hypertensive patients have additional risk factors).
- Tolerability - Persistence on antihypertensive therapy.
- Affordable.
- In line with International Guidelines.
- Confers better treatment outcome on black patients.
- Supported by ALLHAT, HOPE, MICROHOPE, AASK and REIN Studies.